Isoelectric Point Calculator 2.0
Prediction of isoelectric point and pKa dissociation constants using deep learning

Links to other online isoelectric point estimation tools, databases, etc.


Isoelectric point calculation methods

pKa calculation methods

  • H++ program for protein pKa calculations using the Poisson-Boltzmann approach (structure based)
  • MCCE Multi-Conformation Continuum Electrostatics (pKa calculation based on structure)
  • Rosetta pKa (calculation of protein pKa values using Rosetta)

  • Wikipedia articles

    Acknowledgements (aka libraries, tools used):

    http server
    script programming
    web server front-end
    CanvasJS JavaScript charts for web server front-end
    HTML, CSS, and JS templates
    deep learning (front-end)
    deep learning (back-end)
    statistics (CV, sampling, feature selection, etc.)
    some scripts
    Contact: Lukasz P. Kozlowski