Isoelectric Point Calculator 2.0
Prediction of isoelectric point and pKa dissociation constants using deep learning

Isolectric point prediction accuracy on leave-out 25% datasets

Conclusions: IPC2 provides two deep learned models customized for proteins and peptides. Both provide more accurate and robust prediction of isoelectric point.

Results for pKa prediction

Conclusions: The pKa prediction accuracy using IPC2_pKa model is in comparable range to the Rosseta-based approach, yet IPC2_pKa return the predictions within seconds and uses only sequence information.

Contact: Lukasz P. Kozlowski